منابع مشابه
Misbehaving macrophages in the pathogenesis of psoriasis.
Psoriasis is a chronic inflammatory skin disease unique to humans. In this issue of the JCI, 2 studies of very different mouse models of psoriasis both report that macrophages play a key role in inducing psoriasis-like skin disease. Psoriasis is clearly a polygenic, inherited disease of uncontrolled cutaneous inflammation. The debate that currently rages in the field is whether psoriasis is a d...
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Pathophysiology of psoriasis The pathophysiology of psoriasis is multifaceted and dynamic, involving a complex interplay between constitutive cells of the skin and the innate and adaptive immune systems. Until the early 1980s, psoriasis was considered to be primarily a disease of epidermal keratinocyte proliferation, with the cutaneous inflammatory infiltrate a secondary consequence [1]. Howeve...
متن کاملPsoriasis: from pathogenesis to novel therapeutic approaches.
Psoriasis is one of the commonest chronic inflammatory disorders. Its cause is unknown, but a wealth of studies indicate that the disease results from a complex and dynamic interplay between genetic and environmental factors that trigger an excessive inflammatory response in the skin. Dendritic cells and effector T-cells are central in the development of the psoriastic lesion, and cytokines pro...
متن کاملPsoriasis pathophysiology: current concepts of pathogenesis.
Psoriasis vulgaris is a common skin disorder characterised by focal formation of inflamed, raised plaques that constantly shed scales derived from excessive growth of skin epithelial cells. The disease is defined by a series of linked cellular changes in the skin: hyperplasia of epidermal keratinocytes, vascular hyperplasia and ectasia, and infiltration of T lymphocytes, neutrophils, and other ...
متن کاملFactors Involved in the Pathogenesis of Psoriasis
Psoriasis is thought to be an autoimmune disease. Both innate and adaptive immune factors are involved in pathogenesis. Innate immune factors include neutrophils, dendritic cells, mast cells and keratinocytes as well as receptors that they express and cytokines they produce, and the coagulation and complement systems. The adaptive immune factors include mainly the T-lymphocyte subsets and their...
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ژورنال
عنوان ژورنال: International Journal of Experimental Pathology
سال: 2009
ISSN: 0959-9673
DOI: 10.1111/j.1365-2613.2009.00669.x